The emerging role of acetylation in the regulation of autophagy

Ágnes Bánréti, M. Sass, Yacine Graba

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Autophagy is an evolutionarily conserved catabolic process through which different components of the cells are sequestered into double-membrane cytosolic vesicles called autophagosomes, and fated to degradation through fusion with lysosomes. Autophagy plays a major function in many physiological processes including response to different stress factors, energy homeostasis, elimination of cellular organelles and tissue remodeling during development. Consequently, autophagy is strictly controlled and post-translational modifications such as phosphorylation and ubiquitination have long been associated with autophagy regulation. In contrast, the importance of acetylation in autophagy control has only emerged in the last few years. In this review, we summarize how previously identified histone acetylases and deacetylases modify key autophagic effector proteins, and discuss how this has an impact on physiological and pathological cellular processes.

Original languageEnglish
Pages (from-to)819-829
Number of pages11
JournalAutophagy
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Autophagy
Acetylation
Physiological Phenomena
Histone Acetyltransferases
Histone Deacetylases
Ubiquitination
Pathologic Processes
Cellular Structures
Post Translational Protein Processing
Lysosomes
Organelles
Homeostasis
Phosphorylation
Membranes
Proteins

Keywords

  • Acetylation
  • ATG genes
  • Autophagy
  • Deacetylation
  • FOXO
  • Huntington disease
  • Lysine
  • Post-translational modification
  • Protein aggregates

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

The emerging role of acetylation in the regulation of autophagy. / Bánréti, Ágnes; Sass, M.; Graba, Yacine.

In: Autophagy, Vol. 9, No. 6, 06.2013, p. 819-829.

Research output: Contribution to journalArticle

Bánréti, Ágnes ; Sass, M. ; Graba, Yacine. / The emerging role of acetylation in the regulation of autophagy. In: Autophagy. 2013 ; Vol. 9, No. 6. pp. 819-829.
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