The emerging and diverse roles of Src-like adaptor proteins in health and disease

Nikolett Marton, Eszter Baricza, Barbara Érsek, Edit I. Buzás, György Nagy

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

Original languageEnglish
Article number952536
JournalMediators of inflammation
Volume2015
DOIs
Publication statusPublished - Jan 1 2015

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ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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