The electrophysiological effects of opioid receptor-selective antagonists on sheep Purkinje fibres

Marie McIntosh, Kathleen Kane, J. Parratt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The cardiac electrophysiological effects of 16-methylcyprenorphine (M8008), nor-binaltorphimine (NBT) and naltrexone, which are relatively specific opioid antagonists for δ, κ and μ receptors, respectively, were studied in paced (1.5 Hz) sheep Purkinje fibres in vitro. M8008 (1 ng ml-1-10 μg ml-1) caused a concentration-dependent reduction the maximum rate of depolarisation of phase 0 (MRD) and the action potential duration measured at 50% repolarisation, APD50. Neither NBT (10 ng ml-1-10 μg ml-1) nor naltrexone (1 ng ml-1-10 μg ml-1) produced any significant effect on the cardiac action potential. In the presence of a physiological salt solution modified to mimic some of the changes that occur during myocardial ischaemia (i.e. hypoxia, acidosis, hyperkalaemia), M8008 caused a more marked reduction in MRD and prolonged rather than shortened APD50. These results suggest that the reported antiarrhythmic activity of M8008, but not NBT or naltrexone, may be, at least in part, explained by a direct cardiac electrophysiological action.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalEuropean Journal of Pharmacology
Volume210
Issue number1
DOIs
Publication statusPublished - Jan 7 1992

Fingerprint

Purkinje Fibers
Naltrexone
Narcotic Antagonists
Sheep
Action Potentials
Hyperkalemia
Acidosis
Myocardial Ischemia
Salts
norbinaltorphimine

Keywords

  • Cardiac electrophysiology
  • Ischaemia
  • Opioid receptor antagonists
  • Purkinje fibres

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The electrophysiological effects of opioid receptor-selective antagonists on sheep Purkinje fibres. / McIntosh, Marie; Kane, Kathleen; Parratt, J.

In: European Journal of Pharmacology, Vol. 210, No. 1, 07.01.1992, p. 45-51.

Research output: Contribution to journalArticle

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