The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later: Preliminary findings

Jan Volavka, Pál Czobor, Donald W. Goodwin, William F. Gabrielli, Elizabeth C. Penick, Sarnoff A. Mednick, Per Jensen, Joachim Knop, Fini Schulsinger

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background: In 1979 through 1980, electroencephalographic (EEG) responses to an alcohol challenge in 19-year-old sons of alcoholics as well as in sons of nonalcoholic control subjects were examined. The familial risk status of the subjects and greater EEG sensitivity to alcohol were hypothesized to predict the development of alcoholism 10 years later. Methods: In 1990 through 1992, diagnostic interviews were completed to ascertain alcohol and other substance use disorders in these subjects and to update their family history. Results: Updated family history of alcoholism predicted the development of substance dependence. Density of alcoholic relatives (the number of alcoholic relatives divided by the number of known relatives) was positively related to the severity of alcohol use disorders in the probands. Contrary, to expectation, a greater EEG response at age 19 years was not related to the later development of alcohol dependence. Instead, the opposite was observed: a smaller EEG alpha frequency response to alcohol at age 19 years was related to the development of alcohol dependence and high quantity and frequency of alcohol consumption 10 years later. Conclusions: Lower EEG response to a small dose of alcohol may be associated with the later development of alcohol dependence. This result is based on a small number of subjects and should be interpreted with caution. Although this result is opposite to our 1980 hypothesis, it is consistent with much of the recent literature.

Original languageEnglish
Pages (from-to)258-263
Number of pages6
JournalArchives of General Psychiatry
Volume53
Issue number3
DOIs
Publication statusPublished - Mar 1996

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later: Preliminary findings'. Together they form a unique fingerprint.

  • Cite this