Le récepteur de l'élastine-laminine.

Translated title of the contribution: The elastin-laminin receptor

T. Fülöp, M. P. Jacob, J. Wallach, M. Hauck, I. Seres, Z. Varga, L. Robert

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Elastin is a major component of the extracellular matrix. Elastin peptides derived from its degradation are present in human sera. Elastin peptides induce on fibroblasts, phagocytic cells, lymphocytes, smooth muscle cells and endothelial cells, a variety of biological effects mediated by the elastin-laminin receptor which has been demonstrated to be present on the membrane of these cells. The transduction pathway of the ELR receptor involves the activation of phospholipase C (PLC) by a pertussis toxin sensitive G-protein. PLC induces the production of inositol trisphosphate (IP3) leading to the increase of the intracellular free calcium on one hand, and of diacylglycerol (DAG) which stimulates the translocation to the membrane of PKC leading to the phosphorylation of members of the MAPK family, such as p42/p44 MAPK. Considering the multiple biological effects of ELR the elucidation of the complexity of the signaling pathways will help to better modulate it, mainly in pathological situations such as atherosclerosis.

Original languageFrench
Pages (from-to)157-164
Number of pages8
JournalJournal de la Société de biologie
Volume195
Issue number2
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Ageing
  • Cell Biology

Cite this

Fülöp, T., Jacob, M. P., Wallach, J., Hauck, M., Seres, I., Varga, Z., & Robert, L. (2001). Le récepteur de l'élastine-laminine. Journal de la Société de biologie, 195(2), 157-164.