The elastase-mediated pathway of fibrinolysis.

R. Machovich, W. G. Owen

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Plasmin and elastase degrade fibrin and inhibit the blood coagulation system by degrading key proteins. Elastase can facilitate plasmin expression via an alternative pathway of plasminogen activation. Elastase modifies plasminogen to yield a zymogen that is a better substrate for activators than native plasminogen. Furthermore, elastase inactivates the inhibitor system of plasmin and plasminogen activators without affecting plasmin and plasminogen activators. While plasmin activity develops from a blood zymogen as a consequence of activators synthesized and secreted by endothelium and possibly other cells, elastase is secreted in an active form primarily by polymorphonuclear leukocytes. Plasmin and elastase may play mutual roles in thrombolysis, inflammation, and tumour invasion and metastasis.

Original languageEnglish
Pages (from-to)79-90
Number of pages12
JournalBlood Coagulation and Fibrinolysis
Volume1
Issue number1
Publication statusPublished - Mar 1990

Fingerprint

Pancreatic Elastase
Fibrinolysis
Fibrinolysin
Plasminogen Activators
Enzyme Precursors
Plasminogen
Antifibrinolytic Agents
Blood Coagulation
Fibrin
Endothelium
Neutrophils
Neoplasm Metastasis
Inflammation
Neoplasms
Proteins

ASJC Scopus subject areas

  • Hematology

Cite this

The elastase-mediated pathway of fibrinolysis. / Machovich, R.; Owen, W. G.

In: Blood Coagulation and Fibrinolysis, Vol. 1, No. 1, 03.1990, p. 79-90.

Research output: Contribution to journalArticle

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