Az influenza elleni védooltás hatékonysága immunszupprimált gyulladásos bélbetegekben.

Translated title of the contribution: [The efficiency of influenza vaccines in patients with inflammatory bowel disease on immunosuppressive therapy].

Klaudia Farkas, Gabriella Terhes, Judit Deák, Anita Bálint, Ferenc Nagy, Zoltán Szepes, Tibor Wittmann, Tamás Molnár

Research output: Contribution to journalArticle

3 Citations (Scopus)


Inactivated influenza vaccination is recommended yearly for patients with inflammatory bowel disease on immunosuppressive therapy. The aim of our study was to evaluate the immune response to seasonal influenza vaccination in patients with inflammatory bowel disease treated with immunosuppressants. Thirty patients were enrolled in this prospective study. Each patient was diagnosed with inflammatory bowel disease and treated with immunosuppressants. Blood samples were obtained from patients before and one month after influenza vaccination (A/California/7/2009(H1N1), A/Perth/16/2009(H3N2) B/Brisbane/60/2008) to assess the pre-and postimmunization antibody titers. Virus-specific antibodies were measured by ELISA. The vaccine acceptance rate was 53.3%. Local adverse effect occurred in 5 patients. Seven patients developed systemic adverse events. Influenza-like symptoms occurred in 2 patients, although their antibody titers failed to increase significantly. Antibodies to influenza viruses were detected in each patient before the vaccination. The results confirmed that each patient had appropriate antibody titer as correlation of protection even before the immunisation. Seroprotection rates were not influenced by the vaccination. The vaccine seemed to be safe.

Original languageHungarian
Pages (from-to)1870-1874
Number of pages5
JournalOrvosi hetilap
Issue number47
Publication statusPublished - Nov 25 2012


ASJC Scopus subject areas

  • Medicine(all)

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