The efficacy of valnemulin (Econor®) in the control of disease caused by experimental infection of calves with Mycoplasma bovis

L. Stipkovits, Paul H. Ripley, M. Tenk, R. Glávits, T. Molnár, L. Fodor

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Mycoplasma bovis infection was experimentally induced in groups of six young calves. A further group was uninfected and served as a control. Ten days after infection, medication with either enrofloxacin (Baytril, Bayer) or valnemulin (Econor, Novartis) was instituted via the milk replacer for a further 10 days, after which all calves were killed. Infection resulted in depression, pyrexia, inappetance and prominent respiratory signs. Arthritis occurred in two animals and two (unmedicated) animals died. At post-mortem examination extensive lesions were present in the lungs and M. bovis was re-isolated from infected unmedicated calves' lungs. Medication with either enrofloxacin or valnemulin resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss. Isolation of Pasteurella multocida from the calves' lungs was suppressed by both medicaments. Valnemulin resulted in a more rapid reduction of clinical scores and eliminated M. bovis from the lungs more effectively than enrofloxacin.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalResearch in veterinary science
Volume78
Issue number3
DOIs
Publication statusPublished - Jun 1 2005

Keywords

  • Calves
  • Enrofloxacin
  • Experimental infection
  • Mycoplasma bovis
  • Pneumonia
  • Valnemulin

ASJC Scopus subject areas

  • veterinary(all)

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