The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures

Henriette Farkas, László Gyeney, Elemér Gidófalvy, György Füst, Lilian Varga

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Purpose: This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures. Patients and Methods: Twelve patients with a history of edema after dental procedures were administered danazol (600 mg/d) 4 days preoperatively and 4 days postoperatively. The serum levels of complement components were determined preoperatively and postoperatively as well as at 6, 12 and 24 hours in six patients. Results: None of the 12 patients developed angioneurotic edema. The serum levels of the complement components were decreased immediately after surgery and returned to normal within 24 hours. Conclusion: The short-term prophylactic use of danazol in patients with hereditary angioedema undergoing oral surgery is an effective preventive measure.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalJournal of Oral and Maxillofacial Surgery
Volume57
Issue number4
DOIs
Publication statusPublished - Apr 1999

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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