A lacosamid hatékonysága a gyógyszeres kezelési elozmények tükrében. Klinikai tapasztalatok felnottkori parciális epilepsziában

Translated title of the contribution: The efficacy of lacosamide in relation to antiepileptic drug history. Clinical experiences in adult partial epilepsy

Gábor Barcs, Anna Szucs, András Horváth, Anita Kamondi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: A retrospective study in adult partial epilepsy on the efficacy of lacosamide in relation to previous antiepileptic drug experiences. Method: We analysed 3-65 months' data on epilepsy-care of 43 pharmacoresistant partial epilepsy patients treated with lacosamide. Further analysis of antiepileptic drug history was carried out in strictly selected subgroups of patients with good and poor therapeutic response to lacosamide (10 and 9 patients, respectively) for 2-10 years long retrospective follow up. Patients: Adult patients with partial-onset seizures had been treated previously with three or more lifetime antiepileptic drugs without permanent success. Results - Six patients (14%) were seizure free, eleven patients (25%) have experienced important improvement (their seizure-frequency decreased by at least 50%) for more than 12 months. Fourteen patients (32%) improved for less than 6 months and then have relapsed; and add-on lacosamide proved ineffective in 12 patients (28%). Those selected 10 patients successfully treated with lacosamide (seizure free for at least six months) favourably responded to carbamazepine or oxcarbazepine earlier and levetiracetam was ineffective or even caused worsening. The selected lacosamide-unresponsive nine patients responded unfavourably to carbamazepine or oxcarbazepine earlier. Fifteen patients (35%) suffered side effects as dizziness or sleepiness, in 11 of them lacosamide was combined with a "traditional" sodium-channal blocker antiepileptic drug. Conclusion: Lacosamide is an effective add-on antiepileptic drug in difficult-to treat adult partial epilepsy patients. Our data suggest that good lacosamide response may be expected in those patients who reacted favourably to "traditional" sodium-channel blocker carabamazepine or oxcarbazepine earlier.

Translated title of the contributionThe efficacy of lacosamide in relation to antiepileptic drug history. Clinical experiences in adult partial epilepsy
Original languageHungarian
Pages (from-to)23-29
Number of pages7
JournalIdeggyogyaszati szemle
Volume68
Issue number1-2
Publication statusPublished - Jan 30 2015

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The efficacy of lacosamide in relation to antiepileptic drug history. Clinical experiences in adult partial epilepsy'. Together they form a unique fingerprint.

  • Cite this