Féregellenes készitmények kis strongylidák elleni hatékonysága egy hazai ménesben

Translated title of the contribution: The efficacy of four anthelmintics against small strongyles in a stud farm in Hungary

R. Farkas, Éva Hell, Tímea Pálfi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The species of subfamily Cyathostominae (Nematoda: Strongylidae), called as small strongyles are the most common nematodes of horses worldwide. The majority of anthelmintics are ineffective or partly effective against the mucosal larval stages of these parasites which can cause larval cyathostominosis (larval cyathostomosis) resulting in mild or severe clinical signs, mainly in chronic diarrhoea. The other problem caused by this parasitosis is related to anthelmintic resistance developed in cyathostomes against benzimidazoles and pyrantels which have been detected in many countries. For a few decades benzimidazoles and macrocyclic lactones have been used for anthelmintic treatments of horses in Hungary. However, no field or laboratory studies have evaluated the efficacy of the products against the small strongyles. For this reason the efficacy of Eqvalan paste (ivermectin), Equest 2% oral gel (moxidectin), Promectin Plus paste (abamectin and praziquantel) and PALO gel (mebendazole) was checked with an in vivo method (Fecal Egg Count Reduction Test=FECRT). Ten horses of each group infected with small strongyles were treated once with a product and ten animals of the fifth group remained untreated as controls. According to the results of FECRT, the efficacy of products containing ivermectin or moxidectin was 99% (confidence interval at the level of 95% was between 93 and 100) and 100% for abamectin. The mean fecal egg count reduction was only 18% in horses treated with PALO gel indicating that a high level of mebendazole resistance occurred in the local cyathostome populations. Based on the first detection of benzimidazole-resistant small strongyles in Hungary the authors discuss the risk factors for the development of anthelmintic resistance and those issues that should be taken into account for delaying the development of drug resistance in equine cyathostomin nematodes.

Original languageHungarian
Pages (from-to)291-297
Number of pages7
JournalMagyar Allatorvosok Lapja
Volume128
Issue number5
Publication statusPublished - 2006

Fingerprint

Cyathostominae
Anthelmintics
Hungary
anthelmintics
abamectin
Horses
Ivermectin
farms
Benzimidazoles
Mebendazole
Gels
Ointments
horses
Ovum
mebendazole
benzimidazoles
moxidectin
fecal egg count
Nematoda
gels

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Féregellenes készitmények kis strongylidák elleni hatékonysága egy hazai ménesben. / Farkas, R.; Hell, Éva; Pálfi, Tímea.

In: Magyar Allatorvosok Lapja, Vol. 128, No. 5, 2006, p. 291-297.

Research output: Contribution to journalArticle

@article{7a66ed4944164d4090b3ff958bdf6ffc,
title = "F{\'e}regellenes k{\'e}szitm{\'e}nyek kis strongylid{\'a}k elleni hat{\'e}konys{\'a}ga egy hazai m{\'e}nesben",
abstract = "The species of subfamily Cyathostominae (Nematoda: Strongylidae), called as small strongyles are the most common nematodes of horses worldwide. The majority of anthelmintics are ineffective or partly effective against the mucosal larval stages of these parasites which can cause larval cyathostominosis (larval cyathostomosis) resulting in mild or severe clinical signs, mainly in chronic diarrhoea. The other problem caused by this parasitosis is related to anthelmintic resistance developed in cyathostomes against benzimidazoles and pyrantels which have been detected in many countries. For a few decades benzimidazoles and macrocyclic lactones have been used for anthelmintic treatments of horses in Hungary. However, no field or laboratory studies have evaluated the efficacy of the products against the small strongyles. For this reason the efficacy of Eqvalan paste (ivermectin), Equest 2{\%} oral gel (moxidectin), Promectin Plus paste (abamectin and praziquantel) and PALO gel (mebendazole) was checked with an in vivo method (Fecal Egg Count Reduction Test=FECRT). Ten horses of each group infected with small strongyles were treated once with a product and ten animals of the fifth group remained untreated as controls. According to the results of FECRT, the efficacy of products containing ivermectin or moxidectin was 99{\%} (confidence interval at the level of 95{\%} was between 93 and 100) and 100{\%} for abamectin. The mean fecal egg count reduction was only 18{\%} in horses treated with PALO gel indicating that a high level of mebendazole resistance occurred in the local cyathostome populations. Based on the first detection of benzimidazole-resistant small strongyles in Hungary the authors discuss the risk factors for the development of anthelmintic resistance and those issues that should be taken into account for delaying the development of drug resistance in equine cyathostomin nematodes.",
author = "R. Farkas and {\'E}va Hell and T{\'i}mea P{\'a}lfi",
year = "2006",
language = "Hungarian",
volume = "128",
pages = "291--297",
journal = "Magyar Allatorvosok Lapja",
issn = "0025-004X",
publisher = "Magyar Mezogazdasag Ltd",
number = "5",

}

TY - JOUR

T1 - Féregellenes készitmények kis strongylidák elleni hatékonysága egy hazai ménesben

AU - Farkas, R.

AU - Hell, Éva

AU - Pálfi, Tímea

PY - 2006

Y1 - 2006

N2 - The species of subfamily Cyathostominae (Nematoda: Strongylidae), called as small strongyles are the most common nematodes of horses worldwide. The majority of anthelmintics are ineffective or partly effective against the mucosal larval stages of these parasites which can cause larval cyathostominosis (larval cyathostomosis) resulting in mild or severe clinical signs, mainly in chronic diarrhoea. The other problem caused by this parasitosis is related to anthelmintic resistance developed in cyathostomes against benzimidazoles and pyrantels which have been detected in many countries. For a few decades benzimidazoles and macrocyclic lactones have been used for anthelmintic treatments of horses in Hungary. However, no field or laboratory studies have evaluated the efficacy of the products against the small strongyles. For this reason the efficacy of Eqvalan paste (ivermectin), Equest 2% oral gel (moxidectin), Promectin Plus paste (abamectin and praziquantel) and PALO gel (mebendazole) was checked with an in vivo method (Fecal Egg Count Reduction Test=FECRT). Ten horses of each group infected with small strongyles were treated once with a product and ten animals of the fifth group remained untreated as controls. According to the results of FECRT, the efficacy of products containing ivermectin or moxidectin was 99% (confidence interval at the level of 95% was between 93 and 100) and 100% for abamectin. The mean fecal egg count reduction was only 18% in horses treated with PALO gel indicating that a high level of mebendazole resistance occurred in the local cyathostome populations. Based on the first detection of benzimidazole-resistant small strongyles in Hungary the authors discuss the risk factors for the development of anthelmintic resistance and those issues that should be taken into account for delaying the development of drug resistance in equine cyathostomin nematodes.

AB - The species of subfamily Cyathostominae (Nematoda: Strongylidae), called as small strongyles are the most common nematodes of horses worldwide. The majority of anthelmintics are ineffective or partly effective against the mucosal larval stages of these parasites which can cause larval cyathostominosis (larval cyathostomosis) resulting in mild or severe clinical signs, mainly in chronic diarrhoea. The other problem caused by this parasitosis is related to anthelmintic resistance developed in cyathostomes against benzimidazoles and pyrantels which have been detected in many countries. For a few decades benzimidazoles and macrocyclic lactones have been used for anthelmintic treatments of horses in Hungary. However, no field or laboratory studies have evaluated the efficacy of the products against the small strongyles. For this reason the efficacy of Eqvalan paste (ivermectin), Equest 2% oral gel (moxidectin), Promectin Plus paste (abamectin and praziquantel) and PALO gel (mebendazole) was checked with an in vivo method (Fecal Egg Count Reduction Test=FECRT). Ten horses of each group infected with small strongyles were treated once with a product and ten animals of the fifth group remained untreated as controls. According to the results of FECRT, the efficacy of products containing ivermectin or moxidectin was 99% (confidence interval at the level of 95% was between 93 and 100) and 100% for abamectin. The mean fecal egg count reduction was only 18% in horses treated with PALO gel indicating that a high level of mebendazole resistance occurred in the local cyathostome populations. Based on the first detection of benzimidazole-resistant small strongyles in Hungary the authors discuss the risk factors for the development of anthelmintic resistance and those issues that should be taken into account for delaying the development of drug resistance in equine cyathostomin nematodes.

UR - http://www.scopus.com/inward/record.url?scp=33845337638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845337638&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33845337638

VL - 128

SP - 291

EP - 297

JO - Magyar Allatorvosok Lapja

JF - Magyar Allatorvosok Lapja

SN - 0025-004X

IS - 5

ER -