The efficacy and safety of human oocyte vitrification

Zsolt Peter Nagy, Ching Chien Chang, Daniel B. Shapiro, Diana Patricia Bernal, Hilton I. Kort, Gábor Vajta

Research output: Contribution to journalReview article

62 Citations (Scopus)


Vitrification is now a widely applied and highly successful approach for cryopreservation in reproductive biology. Rapidly increasing data prove that it is also a highly efficient technique for low-temperature storage of human oocytes. The latest approaches with appropriately selected cryoprotectants, tools and techniques, and properly adjusted parameters allow close to 100% morphological survival rates, and in vitro embryo development, as well pregnancy and implantation rates, comparable with those achieved with fresh oocytes. With standardization of the technique and elimination of biosafety problems by preserving all the positive features, vitrification may become a common part of the everyday routine in a human embryo laboratory, and it may offer a solution for various medical and social situations as well as for simple logistic problems commonly occurring in assisted reproduction.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalSeminars in Reproductive Medicine
Issue number6
Publication statusPublished - Nov 17 2009



  • Cryopreservation
  • DMSO
  • Oocyte
  • Sterile
  • Vitrification

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynaecology
  • Physiology (medical)

Cite this

Nagy, Z. P., Chang, C. C., Shapiro, D. B., Bernal, D. P., Kort, H. I., & Vajta, G. (2009). The efficacy and safety of human oocyte vitrification. Seminars in Reproductive Medicine, 27(6), 450-455.