The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis

E. Endreffy, S. Túri, Zoltán Lászik, C. Bereczki, Katalin Kása

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of vitamin E on tissue oxidation, kidney function and morphology were studied in rats with nephrotoxic nephritis (NTN). Thirty-six nephritic animals received no treatment (group 1), while 36 were treated with vitamin E (group 2). Twenty-four hours after the administration of anti-glomerular basement membrane antibody, sulfhydryl-containing renal protein was significantly lower in group 1 than in group 2 (0.70±0.16 and 1.08±0.06 mmol/100 g kidney tissue, respectively), suggesting a free oxygen radical scavenging effect of vitamin E in group 2. The difference was similar on day 14. The creatinine clearance was significantly lower in group 1 than in group 2 on day 1 (40±30 and 204±60 μl/min per 100 g body weight, respectively). The protein excretion was initially high in both groups, but a significant decrease was detected in group 2 relative to group 1 on day 14 (25±18 and 92±38 mg/24 h, respectively). The morphological changes were less severe in group 2. Vitamin E treatment did not alter any of the above values significantly in healthy animals. The release of oxygen free radicals in NTN might play an important role in the pathogenesis, which can be influenced by free radical scavengers through changes in kidney function and morphology.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalPediatric Nephrology
Volume5
Issue number3
DOIs
Publication statusPublished - May 1991

Fingerprint

Glomerular Basement Membrane
Nephritis
Vitamin E
Kidney
Free Radicals
Reactive Oxygen Species
Free Radical Scavengers
Creatinine
Proteins
Body Weight
Antibodies

Keywords

  • Nephrotoxic (anti-glomerular basement membrane) nephritis
  • Tissue oxidation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis. / Endreffy, E.; Túri, S.; Lászik, Zoltán; Bereczki, C.; Kása, Katalin.

In: Pediatric Nephrology, Vol. 5, No. 3, 05.1991, p. 312-317.

Research output: Contribution to journalArticle

@article{ff3c6083fdeb419b95652c46ffb5608a,
title = "The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis",
abstract = "The effects of vitamin E on tissue oxidation, kidney function and morphology were studied in rats with nephrotoxic nephritis (NTN). Thirty-six nephritic animals received no treatment (group 1), while 36 were treated with vitamin E (group 2). Twenty-four hours after the administration of anti-glomerular basement membrane antibody, sulfhydryl-containing renal protein was significantly lower in group 1 than in group 2 (0.70±0.16 and 1.08±0.06 mmol/100 g kidney tissue, respectively), suggesting a free oxygen radical scavenging effect of vitamin E in group 2. The difference was similar on day 14. The creatinine clearance was significantly lower in group 1 than in group 2 on day 1 (40±30 and 204±60 μl/min per 100 g body weight, respectively). The protein excretion was initially high in both groups, but a significant decrease was detected in group 2 relative to group 1 on day 14 (25±18 and 92±38 mg/24 h, respectively). The morphological changes were less severe in group 2. Vitamin E treatment did not alter any of the above values significantly in healthy animals. The release of oxygen free radicals in NTN might play an important role in the pathogenesis, which can be influenced by free radical scavengers through changes in kidney function and morphology.",
keywords = "Nephrotoxic (anti-glomerular basement membrane) nephritis, Tissue oxidation",
author = "E. Endreffy and S. T{\'u}ri and Zolt{\'a}n L{\'a}szik and C. Bereczki and Katalin K{\'a}sa",
year = "1991",
month = "5",
doi = "10.1007/BF00867490",
language = "English",
volume = "5",
pages = "312--317",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis

AU - Endreffy, E.

AU - Túri, S.

AU - Lászik, Zoltán

AU - Bereczki, C.

AU - Kása, Katalin

PY - 1991/5

Y1 - 1991/5

N2 - The effects of vitamin E on tissue oxidation, kidney function and morphology were studied in rats with nephrotoxic nephritis (NTN). Thirty-six nephritic animals received no treatment (group 1), while 36 were treated with vitamin E (group 2). Twenty-four hours after the administration of anti-glomerular basement membrane antibody, sulfhydryl-containing renal protein was significantly lower in group 1 than in group 2 (0.70±0.16 and 1.08±0.06 mmol/100 g kidney tissue, respectively), suggesting a free oxygen radical scavenging effect of vitamin E in group 2. The difference was similar on day 14. The creatinine clearance was significantly lower in group 1 than in group 2 on day 1 (40±30 and 204±60 μl/min per 100 g body weight, respectively). The protein excretion was initially high in both groups, but a significant decrease was detected in group 2 relative to group 1 on day 14 (25±18 and 92±38 mg/24 h, respectively). The morphological changes were less severe in group 2. Vitamin E treatment did not alter any of the above values significantly in healthy animals. The release of oxygen free radicals in NTN might play an important role in the pathogenesis, which can be influenced by free radical scavengers through changes in kidney function and morphology.

AB - The effects of vitamin E on tissue oxidation, kidney function and morphology were studied in rats with nephrotoxic nephritis (NTN). Thirty-six nephritic animals received no treatment (group 1), while 36 were treated with vitamin E (group 2). Twenty-four hours after the administration of anti-glomerular basement membrane antibody, sulfhydryl-containing renal protein was significantly lower in group 1 than in group 2 (0.70±0.16 and 1.08±0.06 mmol/100 g kidney tissue, respectively), suggesting a free oxygen radical scavenging effect of vitamin E in group 2. The difference was similar on day 14. The creatinine clearance was significantly lower in group 1 than in group 2 on day 1 (40±30 and 204±60 μl/min per 100 g body weight, respectively). The protein excretion was initially high in both groups, but a significant decrease was detected in group 2 relative to group 1 on day 14 (25±18 and 92±38 mg/24 h, respectively). The morphological changes were less severe in group 2. Vitamin E treatment did not alter any of the above values significantly in healthy animals. The release of oxygen free radicals in NTN might play an important role in the pathogenesis, which can be influenced by free radical scavengers through changes in kidney function and morphology.

KW - Nephrotoxic (anti-glomerular basement membrane) nephritis

KW - Tissue oxidation

UR - http://www.scopus.com/inward/record.url?scp=0025863244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025863244&partnerID=8YFLogxK

U2 - 10.1007/BF00867490

DO - 10.1007/BF00867490

M3 - Article

VL - 5

SP - 312

EP - 317

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 3

ER -