The effects of somatostatin and some of its tetrapeptide fragments on ethanol-induced gastric mucosal erosion in rat

F. László, I. Pávó, B. Penke, G. A. Bálint

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A study was made of the cytoprotective effects of somatostatin (SRIF) and its 3-6, 5-8, 7-10, 9-12 and 11-14 tetrapeptide fragments on absolute ethanol-induced haemorrhagic erosions in the stomach of rat. The SRIF molecule was found to prevent the gastric erosions induced by ethanol. The 7-10 and 11-14 fragments exhibited similar properties. There are two peaks in the cytoprotective dose-response curves. It is concluded that various fragments of SRIF can also exert cytoprotective effects.

Original languageEnglish
Pages (from-to)1123-1126
Number of pages4
JournalLife Sciences
Volume41
Issue number9
DOIs
Publication statusPublished - Aug 31 1987

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Somatostatin
Rats
Erosion
Stomach
Ethanol
Molecules

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effects of somatostatin and some of its tetrapeptide fragments on ethanol-induced gastric mucosal erosion in rat. / László, F.; Pávó, I.; Penke, B.; Bálint, G. A.

In: Life Sciences, Vol. 41, No. 9, 31.08.1987, p. 1123-1126.

Research output: Contribution to journalArticle

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