The effects of somatostatin and somatostatin antiserum on the retention of passive avoidance behavior after neofrontal decortication in rats

G. A. Romanova, M. Yu Karganov, T. Kadar, G. Telegdy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rats were tested for passive avoidance behavior in a one-trial step-through learning paradigm. After the learning trial, the animals underwent neofrontal decortication or sham operation. On the 8th day after operation, the lesioned pr sham-operated rats received intracerebroventricular (ICV) injections of somatostatin (SST; 4 μg/2 μl) or somatostatin antiserum (SST-AB; 2 μl) 1 hr before the retention test. Decortication alone decreased the latency in comparison to that in the sham-operated group, and ICV treatment did not influence this impairment. After treatment with SST-AB the latency decreased, indicating that endogenous SST may play a role in the maintenance of normal memory processes.

Original languageEnglish
Pages (from-to)1035-1036
Number of pages2
JournalPhysiology and Behavior
Volume47
Issue number5
DOIs
Publication statusPublished - May 1990

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Keywords

  • Neofrontal decortication
  • Passive avoidance behavior
  • Somatostatin
  • Somatostatin antiserum

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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