The effects of somatostatin and somatostatin antiserum on the retention of passive avoidance behavior after neofrontal decortication in rats

G. A. Romanova, M. Yu Karganov, T. Kadar, G. Telegdy

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2 Citations (Scopus)


Rats were tested for passive avoidance behavior in a one-trial step-through learning paradigm. After the learning trial, the animals underwent neofrontal decortication or sham operation. On the 8th day after operation, the lesioned pr sham-operated rats received intracerebroventricular (ICV) injections of somatostatin (SST; 4 μg/2 μl) or somatostatin antiserum (SST-AB; 2 μl) 1 hr before the retention test. Decortication alone decreased the latency in comparison to that in the sham-operated group, and ICV treatment did not influence this impairment. After treatment with SST-AB the latency decreased, indicating that endogenous SST may play a role in the maintenance of normal memory processes.

Original languageEnglish
Pages (from-to)1035-1036
Number of pages2
JournalPhysiology and Behavior
Issue number5
Publication statusPublished - May 1990



  • Neofrontal decortication
  • Passive avoidance behavior
  • Somatostatin
  • Somatostatin antiserum

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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