The effects of receptor blockers on atrial natriuretic peptide-induced action on passive avoidance behavior in rats

Amelia Bidzseranova, Gabor Toth, Gyula Telegdy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In previous experiments, it was shown that rat atrial natriuretic peptide (rANP1-28) is able to increase the passive avoidance latency in a dose-dependent manner in the learning and consolidation phase (3). In order to clarify whether ANP has a direct action on this behavioral paradigm, or whether the action is mediated by neurotransmitters, rats were pretreated with different receptor blockers. The selected doses of the different receptor blockers could themselves not influence the behavioral paradigms. Haloperidol or atropine blocked the action of ANP on the consolidation of the passive avoidance response. Phenoxybenzamine, propranolol, methysergide, bicuculline and naloxone were ineffective. The data suggest that dopaminergic and cholinergic mediations are involved in the action of ANP on the passive avoidance response.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume40
Issue number2
DOIs
Publication statusPublished - Oct 1991

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Keywords

  • Atrial natriuretic peptide
  • Avoidance behavior
  • Receptor blockers

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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