The effects of protein synthesis inhibitors on imprinting

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The effects of puromycin and cycloheximide on memory of chicks were examined in an imprinting situation. Prompt approach responses of birds to an imprinting stimulus were inhibited neither by puromycin nor by cycloheximide. But approach response needing a longer presentation of the stimulus, essentially a conditioning, as has been found earlier, was almost completely prevented by intracerebrally administered puromycin. Puromycin also influenced the chicks' stimulus recognition in a discrimination test, without impairing their ability and readiness to make a choice between two stimuli. Some of the results obtained suggest that the puromycin might effect the memory but not by its known effect on the protein synthesis.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalBrain research
Issue number1
Publication statusPublished - Apr 13 1973


ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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