The effects of prostaglandins E2, F(2α), prostacyclin, flurbiprofen and aspirin on arrhythmias resulting from coronary artery ligation in anaesthetized rats

S. J. Coker, J. Parratt

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Abstract

Various prostaglandins and inhibitors of prostaglandin synthesis were administered prior to acute coronary artery ligation in anaesthetized rats and their effects were assessed on the number and severity of the resulting early arrhythmias (ventricular ectopic activity; incidence and duration of ventricular tachycardia and of ventricular fibrillation). Prostaglandin E2 (PGE2), PGF(2α) and prostacyclin all showed antiarrhythmic activity; in contrast, flurbiprofen increased the incidence of ventricular fibrillation and mortality. Both the number of ventricular ectopic beats and the incidence of ventricular fibrillation were reduced by aspirin. The results suggest that the release of endogenous PGE2, PGF(2α) and prostacyclin could reduce early post-infarction ventricular arrhythmias whilst the protective effect of aspirin in this model adds further support for the hypothesis that thromboxane release is involved in the genesis of these arrhythmias.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalBritish Journal of Pharmacology
Volume74
Issue number1
Publication statusPublished - 1981

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Flurbiprofen
Prostaglandins F
Ventricular Fibrillation
Epoprostenol
Dinoprostone
Aspirin
Ligation
Cardiac Arrhythmias
Coronary Vessels
Incidence
Prostaglandin Antagonists
Ventricular Premature Complexes
Thromboxanes
Ventricular Tachycardia
Infarction
Prostaglandins
Mortality

ASJC Scopus subject areas

  • Pharmacology

Cite this

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