The effects of prenatally administered endogenous cannabinoid on rat offspring

T. Wenger, G. Fragkakis, P. Giannikou, N. Yiannikakis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We reported previously that the main psychoactive component of marihuana, Δ9 tetrahydrocannabinol. (THC), when injected prenatally, temporarily inhibited the developing hypothalamo-pituitary system in rat offspring. In the present study, we investigated the effects of the recently described endogenous ligand for the central cannabinoid receptor, arachidonyl-ethanolamide (anandamide, ANA), on the postnatal development of the hypothalamo-pituitary axis (HPA) when administered during the third week of gestation. Rat pups were killed every fifth day from delivery to the 20th postnatal day; gonads, pituitary, and rest of body were weighed, and samples were collected for analysis of gonadotropin releasing hormone in the hypothalamus and luteinizing hormone, follicle stimulating hormone, prolactin, and growth hormone in the pituitaries and sera. The effects of ANA and THC were compared. Both ANA and THC caused predominantly inhibitory effects on the measured parameters. The inhibition was most pronounced immediately following delivery, whereas at the end of the investigated period (20th postnatal day) no differences were observed. We conclude that endogenous and exogenous cannabinoids have similar but slightly different affects on the developing HPA and that the action is transitory. We postulate that ANA probably acts via central cannabinoid receptors and/or neuroendocrine receptors to function as a neuromodulator.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume58
Issue number2
DOIs
Publication statusPublished - Oct 1997

Fingerprint

Dronabinol
Cannabinoids
Rats
Cannabinoid Receptors
Gonads
Follicle Stimulating Hormone
Cannabis
Luteinizing Hormone
Gonadotropin-Releasing Hormone
Prolactin
Growth Hormone
Hypothalamus
Neurotransmitter Agents
Ligands
Pregnancy
anandamide
Serum

Keywords

  • ANA
  • Anandamide
  • Hypothalamo-pituitary system
  • Offspring
  • Prenatal
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

The effects of prenatally administered endogenous cannabinoid on rat offspring. / Wenger, T.; Fragkakis, G.; Giannikou, P.; Yiannikakis, N.

In: Pharmacology, Biochemistry and Behavior, Vol. 58, No. 2, 10.1997, p. 537-544.

Research output: Contribution to journalArticle

Wenger, T. ; Fragkakis, G. ; Giannikou, P. ; Yiannikakis, N. / The effects of prenatally administered endogenous cannabinoid on rat offspring. In: Pharmacology, Biochemistry and Behavior. 1997 ; Vol. 58, No. 2. pp. 537-544.
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