The effects of plasma from IGA nephropathy patients on vascular prostacyclin and platelet cyclic AMP production

S. Túri, J. Nagy, C. Torday, Z. Havass, C. Bereczky

Research output: Contribution to journalArticle

Abstract

The effects of plasma from 10 IgA nephropathy patients and from ten controls were studied on vascular prostacyclin (PGI2) production, the cyclic AMP (cAMP) level and the aggregation of normal platelets. The ability of the plasma to support PGI2-like activity (PSA) was significantly lower in the group of patients (18.0 ± 13.3%) than in the controls (52.6 ± 12.9%). The concentration of 6-keto-PGF1 alpha in the supernatant of the vascular tissue was also lower following incubation with patient plasma than with control plasma (p < 0.001). The reduced PGI2 released by the patient plasma led to a significantly lower platelet cAMP than that following the control plasma (p < 0.01). There was a significantly positive correlation between the 6-keto-PGF1 alpha and the plasma PSA, and also between both the plasma PSA and 6-keto-PGF1 alpha concentrations and the platelet cAMP level. These findings suggest that a vascular PGI2 defect may cause a reduced cAMP production and an uninhibited aggregation of platelets, which might play a role in the pathogenesis of IgA nephropathy.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 1989

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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