The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation

C. L. Wainwright, J. Parratt, M. Bigaud

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

These studies were performed to investigate a role of PAF in the genesis of life-threatening arrhythmias and platelet aggregation accompanying myocardial ischaemia and reperfusion. Pretreatment with the PAF antagonists SRI 63-441 (10 mgkg-1 iv) and BN 52021 (5 mgkg-1 iv) significantly reduced the number of arrhythmias during a thirty minute coronary artery occlusion period in open-chest anaesthetized greyhounds, particularly ventricular tachycardia. Both drugs also reduced the incidence of ventricular fibrillation resulting from reperfusion of the myocardium. Myocardial ischaemia in control animals resulted in a marked fall in platelet count in blood draining the ischaemic area, which was abolished by both SRI 630-441 and BN 52021. These results suggest a role for PAF in the genesis of ischaemia and reperfusion-induced arrhythmias, possibly by inducing platelet aggregation.

Original languageEnglish
JournalBiomedica Biochimica Acta
Volume47
Issue number10-11
Publication statusPublished - 1988

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ginkgolide B
Platelets
Platelet Aggregation
Reperfusion
Cardiac Arrhythmias
Ischemia
Agglomeration
Myocardial Ischemia
Myocardial Reperfusion
Coronary Occlusion
Ventricular Fibrillation
Ventricular Tachycardia
Platelet Count
Coronary Vessels
Myocardium
Animals
Blood
Thorax
Incidence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry

Cite this

The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation. / Wainwright, C. L.; Parratt, J.; Bigaud, M.

In: Biomedica Biochimica Acta, Vol. 47, No. 10-11, 1988.

Research output: Contribution to journalArticle

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