The effects of the noradrenergic agent Clonidine on GH secretion of the adenohypophysis were studied in 10 healthy volunteers and 11 acromegalic patients. Orally administered Clonidine led to a considerable serum human growth hormone (GH) level increase in the healthy individuals. In the acromegalic patients the Clonidine resulted in a slight, but not significant GH increase. These results support the findings that the mechanism of noradrenergic regulation of serum GH secretion is impaired in acromegaly.
|Number of pages||3|
|Journal||Journal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology|
|Publication status||Published - Aug 1984|
- growth hormone level
- noradrenergic regulation
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism