The effects of oestrogen, ACTH and cortisone administration and hypophysectomy on histological changes induced by unilateral renal pedicle clamping

F. László, Z. Monus

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A study was made in rats of the histologic changes occurring in the kidney after temporary application of clamps to the renal pedicle following estrogen, ACTH and cortisone treatments and removal of the pituitary. It was found that the tubular damage is increased to a small extent by estrogen administration and to a more significant degree by ACTH and cortisone treatments. In rats hypophysectomized for several weeks the tubular necrosis either did not occur at all or only to an extremely mild degree. The investigations suggest that the change in sensitivity of the tubular epithelial cells to hypoxia may play a role in the development of the renal cortical necrosis induced by hormone treatment.

Original languageEnglish
Pages (from-to)306-311
Number of pages6
JournalBritish Journal of Experimental Pathology
Volume54
Issue number3
Publication statusPublished - 1973

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Hypophysectomy
Cortisone
Constriction
Adrenocorticotropic Hormone
Estrogens
Kidney Cortex Necrosis
Kidney
Cell Hypoxia
Necrosis
Epithelial Cells
Hormones

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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abstract = "A study was made in rats of the histologic changes occurring in the kidney after temporary application of clamps to the renal pedicle following estrogen, ACTH and cortisone treatments and removal of the pituitary. It was found that the tubular damage is increased to a small extent by estrogen administration and to a more significant degree by ACTH and cortisone treatments. In rats hypophysectomized for several weeks the tubular necrosis either did not occur at all or only to an extremely mild degree. The investigations suggest that the change in sensitivity of the tubular epithelial cells to hypoxia may play a role in the development of the renal cortical necrosis induced by hormone treatment.",
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AB - A study was made in rats of the histologic changes occurring in the kidney after temporary application of clamps to the renal pedicle following estrogen, ACTH and cortisone treatments and removal of the pituitary. It was found that the tubular damage is increased to a small extent by estrogen administration and to a more significant degree by ACTH and cortisone treatments. In rats hypophysectomized for several weeks the tubular necrosis either did not occur at all or only to an extremely mild degree. The investigations suggest that the change in sensitivity of the tubular epithelial cells to hypoxia may play a role in the development of the renal cortical necrosis induced by hormone treatment.

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