The effects of high-altitude exposure on reactive oxygen and nitrogen species

Z. Radák, Zoltan Acs, Zoltan Bori, A. Taylor, Hu Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

High-altitude exposure that results in decreased levels of oxygen pressure, which could lead to hypoxia, can activate a number of sources that can generate reactive oxygen and nitrogen species (RONS). Enhanced formation of RONS causes oxidative damage, which impacts cellular function and could seriously impair organ function. In addition, high altitude appears to weaken the enzymatic and nonenzymatic antioxidant systems. Indeed, recent data suggest that the expression of Mn-SOD in skeletal muscle of mountaineers, who stayed for more than 6 weeks above 6,000 m, decreased significantly 1 week after leaving that altitude. Moreover, the expression of Ku70, which plays an important role in DNA repair, increased after exposure to high altitude, indicating increased DNA damage. Therefore, it appears that increased nutritional uptake of antioxidant vitamins reduce altitude-induced oxidative damage. The pattern of high-altitude exposure-associated oxidative damage is similar to ischemia/reperfusion injury. The adaptive process for this oxidative challenge is relatively long, and physical exercise or enhanced levels of physical activity at high altitude exacerbate the extent of the oxidative challenge. Therefore, special attention must be given to any and all processes which modulate the degree of oxidative stress.

Original languageEnglish
Title of host publicationSystems Biology of Free Radicals and Antioxidants
PublisherSpringer-Verlag Berlin Heidelberg
Pages407-416
Number of pages10
Volume9783642300189
ISBN (Print)9783642300189, 3642300170, 9783642300172
DOIs
Publication statusPublished - May 1 2014

Fingerprint

Reactive Nitrogen Species
Reactive Oxygen Species
Antioxidants
Reperfusion Injury
Vitamins
DNA Repair
DNA Damage
Superoxide Dismutase
Skeletal Muscle
Oxidative Stress
Exercise
Oxygen
Pressure

Keywords

  • Acute mountain sickness
  • Antioxidants
  • High altitude
  • Oxidative damage
  • Oxidative stress
  • Reactive oxygen and nitrogen species

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Radák, Z., Acs, Z., Bori, Z., Taylor, A., & Yang, H. (2014). The effects of high-altitude exposure on reactive oxygen and nitrogen species. In Systems Biology of Free Radicals and Antioxidants (Vol. 9783642300189, pp. 407-416). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_28

The effects of high-altitude exposure on reactive oxygen and nitrogen species. / Radák, Z.; Acs, Zoltan; Bori, Zoltan; Taylor, A.; Yang, Hu.

Systems Biology of Free Radicals and Antioxidants. Vol. 9783642300189 Springer-Verlag Berlin Heidelberg, 2014. p. 407-416.

Research output: Chapter in Book/Report/Conference proceedingChapter

Radák, Z, Acs, Z, Bori, Z, Taylor, A & Yang, H 2014, The effects of high-altitude exposure on reactive oxygen and nitrogen species. in Systems Biology of Free Radicals and Antioxidants. vol. 9783642300189, Springer-Verlag Berlin Heidelberg, pp. 407-416. https://doi.org/10.1007/978-3-642-30018-9_28
Radák Z, Acs Z, Bori Z, Taylor A, Yang H. The effects of high-altitude exposure on reactive oxygen and nitrogen species. In Systems Biology of Free Radicals and Antioxidants. Vol. 9783642300189. Springer-Verlag Berlin Heidelberg. 2014. p. 407-416 https://doi.org/10.1007/978-3-642-30018-9_28
Radák, Z. ; Acs, Zoltan ; Bori, Zoltan ; Taylor, A. ; Yang, Hu. / The effects of high-altitude exposure on reactive oxygen and nitrogen species. Systems Biology of Free Radicals and Antioxidants. Vol. 9783642300189 Springer-Verlag Berlin Heidelberg, 2014. pp. 407-416
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