The effects of glucocorticoids and a glucocorticoid antagonist (RU 38486) on experimental acute pancreatitis in rat.

G. Lázár, J. Varga, G. Lazar, E. Duda, T. Takács, A. Balogh, J. Lonovics

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of glucocorticoids on acute pancreatitis are a matter of dispute. In animal experiments, dexamethasone and hydrocortisone significantly decreased the serum amylase activities 8 hours after the induction of pancreatitis. In the dexamethasone treated group, the serum IL-6 level was significantly decreased at 4 and 8 hours, while in the hydrocortisone treated group, all the IL-6 values were significantly diminished vs. the control group. As compared to the control, a glucocorticoid antagonist (RU 38486) did not influence the serum amylase activity, but significantly increased the serum IL-6 level. These results suggest that glucocorticoids may play a role in the control of pancreatitis caused by inhibition of cytokine production.

Original languageEnglish
Pages (from-to)190-191
Number of pages2
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
Publication statusPublished - 1997

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Mifepristone
Pancreatitis
Glucocorticoids
Interleukin-6
Amylases
Serum
Dexamethasone
Hydrocortisone
Dissent and Disputes
Cytokines
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

The effects of glucocorticoids and a glucocorticoid antagonist (RU 38486) on experimental acute pancreatitis in rat. / Lázár, G.; Varga, J.; Lazar, G.; Duda, E.; Takács, T.; Balogh, A.; Lonovics, J.

In: Acta Chirurgica Hungarica, Vol. 36, No. 1-4, 1997, p. 190-191.

Research output: Contribution to journalArticle

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