The effects of five weeks treatment with dinitro-o-cresol- or trifluralin-containing pesticides on the germ cells of male mice

M. Nehez, A. Selypes, A. Paldy, E. Mazzag, G. Berencsi, K. Jármay

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of two pesticides, the insecticide-herbicide Krezonit E, which contains 50% dinitro-o-cresol, and the herbicide Olitref, which contains 26% trifluralin (2,6-dinitro-N,N-dipropyl-4-trifluoromethylalaniline), on i.p. doses of 0.6 mg kg-1 for Krezonit E and 6.0 mg kg-1 for Olitref. These doses are 1% of the i.p. LD50. Cytogenic analysis of germ cells carried out from 3 weeks onwards after the last treatment day showed that Olitref significantly increased the frequency of germinal chromosomal abnormalities at 6-7 weeks after treatment. This pesticide increased the frequency of autosomal univalents X/Y separations at meiotic metaphase and multivalent configurations. Krezonit E did not increase significantly the number of chromosomal abnormalities, although there was some increase at 3 weeks, mainly in the form of autosomal univalents.

Original languageEnglish
Pages (from-to)179-180
Number of pages2
JournalJournal of Applied Toxicology
Volume2
Issue number4
DOIs
Publication statusPublished - 1982

Fingerprint

Trifluralin
Herbicides
Pesticides
Germ Cells
Chromosome Aberrations
Cells
Lethal Dose 50
Metaphase
Insecticides
2-cresol

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

The effects of five weeks treatment with dinitro-o-cresol- or trifluralin-containing pesticides on the germ cells of male mice. / Nehez, M.; Selypes, A.; Paldy, A.; Mazzag, E.; Berencsi, G.; Jármay, K.

In: Journal of Applied Toxicology, Vol. 2, No. 4, 1982, p. 179-180.

Research output: Contribution to journalArticle

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