Az osztrogenhiany es a hormonpotlo kezeles hatasai patkany kis arteriainak biomechanikai tulajdonsagaira

Translated title of the contribution: The effects of estrogen deficiency and hormone replacement therapy on the biomechanical properties of small arteries in rats

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1 Citation (Scopus)

Abstract

The authors studied the effects of estrogen deficiency and hormone replacement therapy on the biomechanical properties of small arteries in rats in vitro. 20 nulliparous, non-pregnant female Sprague-Dawley rats were pharmacologically overiectomised by 750 μg/kg triptorelin im. every 4th week and received either 450 μg/kg estradiol propionate or its vehicle im. every week. Ten other animals received only the vehicles of triptorelin and estradiol (control group). After 12 weeks of treatment cylindrical segments of the saphenous artery were isolated and cannulated at both ends. Pressure- diameter curves in the range of 0-200 mmHg were recorded from segments in normal KR with norepinephrine (1.6x10-5 M) and than with papaverine (2.8x10-5 M). The vessel segment near to the examined one was sent for morphological examination. Biomechanical parameters of the vessel wall were calculated based on the pressure diameter curves. Pharmacological ovariectomy decreased, estrogen replacement increased significantly the passive diameter of the arteries. Intrinsic myogenic tone was decreased after castration and restored by estrogen replacement. Reactivity of the vessel wall to norepinephrine was decreased by estrogen deficiency, hormone replacement therapy induced significantly increased vasoconstriction. No histological changes were seen in the examined vessels. Our results are the first description on hormone replacement effects on the biomechanical properties of small arteries. We have found a new, peripheral mechanism for the development of perimenopausal hot flushes as well.

Original languageHungarian
Pages (from-to)103-109
Number of pages7
JournalMagyar Noorvosok Lapja
Volume61
Issue number2
Publication statusPublished - 1998

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Estrogen Replacement Therapy
Hormone Replacement Therapy
Arteries
Triptorelin Pamoate
Estradiol
Norepinephrine
Pressure
Papaverine
Castration
Propionates
Ovariectomy
Vasoconstriction
Sprague Dawley Rats
Estrogens
Hormones
Pharmacology
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Az osztrogenhiany es a hormonpotlo kezeles hatasai patkany kis arteriainak biomechanikai tulajdonsagaira",
abstract = "The authors studied the effects of estrogen deficiency and hormone replacement therapy on the biomechanical properties of small arteries in rats in vitro. 20 nulliparous, non-pregnant female Sprague-Dawley rats were pharmacologically overiectomised by 750 μg/kg triptorelin im. every 4th week and received either 450 μg/kg estradiol propionate or its vehicle im. every week. Ten other animals received only the vehicles of triptorelin and estradiol (control group). After 12 weeks of treatment cylindrical segments of the saphenous artery were isolated and cannulated at both ends. Pressure- diameter curves in the range of 0-200 mmHg were recorded from segments in normal KR with norepinephrine (1.6x10-5 M) and than with papaverine (2.8x10-5 M). The vessel segment near to the examined one was sent for morphological examination. Biomechanical parameters of the vessel wall were calculated based on the pressure diameter curves. Pharmacological ovariectomy decreased, estrogen replacement increased significantly the passive diameter of the arteries. Intrinsic myogenic tone was decreased after castration and restored by estrogen replacement. Reactivity of the vessel wall to norepinephrine was decreased by estrogen deficiency, hormone replacement therapy induced significantly increased vasoconstriction. No histological changes were seen in the examined vessels. Our results are the first description on hormone replacement effects on the biomechanical properties of small arteries. We have found a new, peripheral mechanism for the development of perimenopausal hot flushes as well.",
keywords = "Biomechanics, Estrogen, Hormone replacement therapy, Rat, Small arteries",
author = "N. {\'A}cs and B. Sz{\'e}k{\'a}cs and G. N{\'a}dasy and S. V{\'a}rb{\'i}r{\'o} and R. Kakucz and Z. Miklos and E. Monos",
year = "1998",
language = "Hungarian",
volume = "61",
pages = "103--109",
journal = "Magyar Noorvosok Lapja",
issn = "0025-021X",
publisher = "Magyar Noovos Tarsasag",
number = "2",

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T1 - Az osztrogenhiany es a hormonpotlo kezeles hatasai patkany kis arteriainak biomechanikai tulajdonsagaira

AU - Ács, N.

AU - Székács, B.

AU - Nádasy, G.

AU - Várbíró, S.

AU - Kakucz, R.

AU - Miklos, Z.

AU - Monos, E.

PY - 1998

Y1 - 1998

N2 - The authors studied the effects of estrogen deficiency and hormone replacement therapy on the biomechanical properties of small arteries in rats in vitro. 20 nulliparous, non-pregnant female Sprague-Dawley rats were pharmacologically overiectomised by 750 μg/kg triptorelin im. every 4th week and received either 450 μg/kg estradiol propionate or its vehicle im. every week. Ten other animals received only the vehicles of triptorelin and estradiol (control group). After 12 weeks of treatment cylindrical segments of the saphenous artery were isolated and cannulated at both ends. Pressure- diameter curves in the range of 0-200 mmHg were recorded from segments in normal KR with norepinephrine (1.6x10-5 M) and than with papaverine (2.8x10-5 M). The vessel segment near to the examined one was sent for morphological examination. Biomechanical parameters of the vessel wall were calculated based on the pressure diameter curves. Pharmacological ovariectomy decreased, estrogen replacement increased significantly the passive diameter of the arteries. Intrinsic myogenic tone was decreased after castration and restored by estrogen replacement. Reactivity of the vessel wall to norepinephrine was decreased by estrogen deficiency, hormone replacement therapy induced significantly increased vasoconstriction. No histological changes were seen in the examined vessels. Our results are the first description on hormone replacement effects on the biomechanical properties of small arteries. We have found a new, peripheral mechanism for the development of perimenopausal hot flushes as well.

AB - The authors studied the effects of estrogen deficiency and hormone replacement therapy on the biomechanical properties of small arteries in rats in vitro. 20 nulliparous, non-pregnant female Sprague-Dawley rats were pharmacologically overiectomised by 750 μg/kg triptorelin im. every 4th week and received either 450 μg/kg estradiol propionate or its vehicle im. every week. Ten other animals received only the vehicles of triptorelin and estradiol (control group). After 12 weeks of treatment cylindrical segments of the saphenous artery were isolated and cannulated at both ends. Pressure- diameter curves in the range of 0-200 mmHg were recorded from segments in normal KR with norepinephrine (1.6x10-5 M) and than with papaverine (2.8x10-5 M). The vessel segment near to the examined one was sent for morphological examination. Biomechanical parameters of the vessel wall were calculated based on the pressure diameter curves. Pharmacological ovariectomy decreased, estrogen replacement increased significantly the passive diameter of the arteries. Intrinsic myogenic tone was decreased after castration and restored by estrogen replacement. Reactivity of the vessel wall to norepinephrine was decreased by estrogen deficiency, hormone replacement therapy induced significantly increased vasoconstriction. No histological changes were seen in the examined vessels. Our results are the first description on hormone replacement effects on the biomechanical properties of small arteries. We have found a new, peripheral mechanism for the development of perimenopausal hot flushes as well.

KW - Biomechanics

KW - Estrogen

KW - Hormone replacement therapy

KW - Rat

KW - Small arteries

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