The effects of des-enkephalin-γ-endorphin and des-Tyr1-α-endorphin on regional serotonin metabolism in rat brain

Dirk H.G. Versteeg, E. Ronald de Kloet, Gyula Szabó, Gabor L. Kovács

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Des-enkephalin-γ-endorphin (β-endorphin6-17; DEγE) causes a significant reduction of the serotonin concentration of the raphe area of the mesencephalon and of the dorsal hippocampus of the rat. DEγE does not, however, alter the pargyline-induced accumulation of serotonin in either of these two brain regions or in the mediobasal hypothalamus. Des-Tyr1-α-endorphin (β-endorphin2-16; DTαE), on the other hand, inhibits the accumulation of serotonin following MAO-inhibition by pargyline in all 3 brain regions, while, in addition to causing a transient reduction in the serotonin concentration of the raphe area, it decreases the serotonin concentration of the mediobasal hypothalamus. These results indicate that DEγE and DTαE, which have been shown to exert opposite effects on behavior in various behavioral tests, both affect regional serotonin metabolism in rat brain and that they do so differently.

Original languageEnglish
Pages (from-to)384-388
Number of pages5
JournalBrain research
Volume245
Issue number2
DOIs
Publication statusPublished - Aug 12 1982

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Keywords

  • Des-Tyr-α-endorphin
  • Des-enkephalin-γ-endorphin
  • dorsal hippocampus
  • mediobasal hypothalamus
  • raphe area
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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