The effects of cholinomimetic drugs and atropine on ACTH release

G. B. Makara, E. Stark

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21 Citations (Scopus)


Acetylcholine (1 and 50 μg), carbamylcholine (1 and 10 μg), and oxotremorine (10 μg) were infused into the 3rd ventricle of rats with deafferented medial basal hypothalamus (MBH); infusions failed to stimulate ACTH release as shown by the plasma corticosterone level. Implants of an atropine fluorescein mixture (200-250 μg) inhibited the stress induced rise of plasma corticosterone only when dye from the implant stained large portions of the median eminence and the basal hypothalamus. Atropine implants near the electrodes inhibited the rise in plasma corticosterone usually produced by electrical stimulation in the anterior hypothalamus. Atropine crystals or a 2% atropine sulphate solution placed on the median eminence blocked conduction of action potential in the hypothalamoneurohypophyseal and tubero infundibular pathways. The evidence is discussed for and against the participation of a cholinergic synapse (in the MBH) that activates ACTH release after stressful neural stimuli.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
Issue number1
Publication statusPublished - Jan 1 1976


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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