The effects of bicarbonate and acetate haemodialysis on platelet cyclic AMP concentration, thromboxane B2 release and aggregation

S. Túri, C. Bereczki, Csilla Torday, Zoltán Havass, Márta Németh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of chronic uraemia and serial acetate (HDA) or bicarbonate (HDB) hacmodialysis on the aggregation, thromboxane B2 (TXB2) release and cyclic AMP (cAMP) concentration of platelets from arterial blood were studied in 14 uraemic patients (6 dialysed and 8 conservatively treated) and 10 controls. Platelets from uraemic patients, either dialysed or treated conservatively, exhibited a significantly higher cAMP level (P2 level (P2 formation were observed after HDB than after HDA. The concentration of platelet cAMP and aggregability, and also the platelet cAMP and the TXB2 level showed a significantly negative correlation (r=-0.7, P2 and the aggregability (r=0.67, P2 or aggregation results. The dysfunction of uraemic platelets accompanied by a reduced TXB2 release may be explained by an increased cAMP and a decreased arachidonic acid availability. HDB improves the platelet function to a greater degree than does HDA.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalPediatric Nephrology
Volume5
Issue number3
DOIs
Publication statusPublished - May 1991

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Thromboxane B2
Bicarbonates
Cyclic AMP
Renal Dialysis
Acetates
Blood Platelets
Uremia
Arachidonic Acid

Keywords

  • Cyclic AMP
  • Platelet aggregation
  • Thromboxane B
  • Uraemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

The effects of bicarbonate and acetate haemodialysis on platelet cyclic AMP concentration, thromboxane B2 release and aggregation. / Túri, S.; Bereczki, C.; Torday, Csilla; Havass, Zoltán; Németh, Márta.

In: Pediatric Nephrology, Vol. 5, No. 3, 05.1991, p. 327-331.

Research output: Contribution to journalArticle

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