Auswirkungen der hörforschung auf die klinische arbeit

Translated title of the contribution: The effects of auditory research on clinical practice

I. Sziklai, T. Tóth, U. Zimmermann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent research has shown that only the inner hair cells pass information on to the brain while the outer hair cells serve as an active amplifier and thus stimulate the inner cells. The electromotility of the outer hair cells is very vulnerable. If it is lacking, sensorineuronal hearing loss occurs. Substances, that compete for the chloride combining site of the motor protein prestin, such as salicylate, might have a blocking effect on the regulation of electromotility. On the other hand, the control of the intracellular Ca 2+ level and the intracellular combination of ions in the outer hair cells might protect their electromotile properties against damage caused by harmful substances (ototoxic drugs) or mechanisms (exposition to noise), which would otherwise lead to irreversible sensorineuronal hearing loss. This is because an increase in the intracellular Ca2+ level activates phosphorylating enzymes. Thus the stiffness of the outer hair cells is reduced, causing an increase in electromotility.

Original languageGerman
Pages (from-to)456-461
Number of pages6
JournalHNO
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Outer Auditory Hair Cells
Hearing Loss
Research
Inner Auditory Hair Cells
Salicylates
Noise
Chlorides
Binding Sites
Ions
Brain
Enzymes
Pharmaceutical Preparations
Proteins

Keywords

  • Electromotility
  • Hair cell
  • Hearing research
  • Prestin
  • Sensorineuronal hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Auswirkungen der hörforschung auf die klinische arbeit. / Sziklai, I.; Tóth, T.; Zimmermann, U.

In: HNO, Vol. 51, No. 6, 01.06.2003, p. 456-461.

Research output: Contribution to journalArticle

Sziklai, I. ; Tóth, T. ; Zimmermann, U. / Auswirkungen der hörforschung auf die klinische arbeit. In: HNO. 2003 ; Vol. 51, No. 6. pp. 456-461.
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