The effects of atrial natriuretic peptide on food-reinforced conditioning in rats. Interactions with neurotransmitters

Amelia Bidzseranova, Jony Gueron, G. Tóth, G. Telegdy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of two doses of rat atrial natriuretic peptide (TANP-1-28), 200 and 500 ng, on 6-day acquisition and extinction of food-reinforced conditional learning (conditional stimulus: light) were studied in rats following administration into the lateral cerebroventricle. With the higher dose, there was a tendency for facilitated acquisition and significantly delayed extinction of the positively reinforced learning task. In order to clarify whether the effect of the peptide is obtained through the involvement of neurotransmitters, the experimental animals were pretreated with different receptor blockers in selected doses that did not influence the behavioral test. Haloperidol, atropine, phenoxybenzamine, and propranolol blocked the action of ANP on extinction of the food-reinforced conditioning, whereas naloxone, bicuculline, and methysergide were ineffective. The results suggest that ANP might be considered a modulating agent in a positively reinforced conditional learning task, and that its action might involve dopaminergic, cholinergic, and α- and β-adrenergic mechanisms.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalPhysiology and Behavior
Volume53
Issue number2
DOIs
Publication statusPublished - 1993

Fingerprint

Atrial Natriuretic Factor
Neurotransmitter Agents
Learning
Food
Methysergide
Phenoxybenzamine
Bicuculline
Haloperidol
Naloxone
Atropine
Propranolol
Adrenergic Agents
Cholinergic Agents
Light
Peptides
Conditioning (Psychology)
Psychological Extinction

Keywords

  • Atrial natriuretic peptide
  • Behavior
  • Conditional learning
  • Neurotransmitters
  • Positive reinforcement

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

The effects of atrial natriuretic peptide on food-reinforced conditioning in rats. Interactions with neurotransmitters. / Bidzseranova, Amelia; Gueron, Jony; Tóth, G.; Telegdy, G.

In: Physiology and Behavior, Vol. 53, No. 2, 1993, p. 325-328.

Research output: Contribution to journalArticle

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