The effects of atrial natriuretic peptide on active avoidance behavior in rats. The role of transmitters

A. Bidzseranova, J. Gueron, B. Penke, G. Telegdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Different doses of rat atrial natriuretic peptide (rANP1-28) were tested as regards the extinction of active avoidance behavior following its injection into the lateral brain ventricle in rats. ANP delayed extinction of the active avoidance reflex in a dose-dependent manner. When the animals were pretreated with different receptor blockers in doses which themselves had no action on the extinction of active avoidance behavior, the action of ANP on this paradigm was completely blocked by haloperidol and atropine, whereas phenoxy-benzamine/propranolol, naloxone, bicuculline and methysergide were ineffective. The data suggest that ANP delays the extinction of active avoidance behavior, and the cholinergic and dopaminergic transmitter systems might be involved in this action.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume40
Issue number1
DOIs
Publication statusPublished - 1991

Fingerprint

Avoidance Learning
Atrial Natriuretic Factor
Rats
Transmitters
Methysergide
Bicuculline
Haloperidol
Naloxone
Atropine
Propranolol
Cholinergic Agents
Lateral Ventricles
Brain
Animals
Reflex
Injections
Psychological Extinction

Keywords

  • Active avoidance
  • ANP
  • Transmitters

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

The effects of atrial natriuretic peptide on active avoidance behavior in rats. The role of transmitters. / Bidzseranova, A.; Gueron, J.; Penke, B.; Telegdy, G.

In: Pharmacology, Biochemistry and Behavior, Vol. 40, No. 1, 1991, p. 61-64.

Research output: Contribution to journalArticle

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