The effects of atrial natriuretic peptide (ANP1-28) on corticotropin releasing factor in brain in rats

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13 Citations (Scopus)

Abstract

We have shown that ANP has anxiolytic-like effects in behavioral studies. Since CRF is thought to be involved in emotional state of the brain, the present study was undertaken to follow the possible alterations in corticotropin-releasing factor-like immunoreactivity (CRF-LI) in different regions of the brain in rats following ANP treatment. CRF-LI immunoreactivity was determined in hypothalamic and extrahypothalamic brain areas after central injection of atrial natriuretic peptide 1-28 (ANP1-28) in rats. After various doses of ANP1-28 administration the CRF-LI significantly increased in the hypothalamus, the hippocampus and the frontal cortex. In the amygdala, ANP caused a marked but nonsignificant CRF-LI enhancement. In the basal forebrain, the CRF-LI decreased. These results suggest that ANP1-28 may moderate activation of the CRF-ergic system in the brain which could be related to the neuroendocrine and behavioral action.

Original languageEnglish
Pages (from-to)1351-1356
Number of pages6
JournalLife Sciences
Volume59
Issue number16
DOIs
Publication statusPublished - Sep 13 1996

Keywords

  • atrial natriuretic peptide
  • brain metals
  • corticotropin-releasing factor-like immunoreactivity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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