The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity

Buket Bozkurt Sarikaya, Sevil Zencir, Nehir Unver Somer, Gulen Irem Kaya, Mustafa Ali Onur, Jaume Bastida, Agnes Berenyi, I. Zupkó, Zeki Topcu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this study, narciprimine and arolycoricidine were isolated from G. rizehensis Stern (Amaryllidaceae). The structures of the alkaloids were elucidated by spectroscopic methods (1D NMR, EI-MS). Due to the previous reports on anti-cancer activity of this group of alkaloids, we investigated their effects on DNA topoisomerase reactions, which are known as the cellular targets of a number of chemotherapeutical drugs. The results revealed that arolycoricidine and narciprimine were effective in both type I and type II DNA topoisomerase reactions in a dose-dependent manner. Topoisomerase-interfering ability of these alkaloids partially correlated with cytostaticity assays, using HeLa (cervix adenocarcinoma), MCF7 (breast adenocarcinoma) and A431 (skin epidermoid carcinoma) cells. Our results are discussed in relation to the potential significance of these alkaloids in the course of drug-development studies.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalRecords of Natural Products
Volume6
Issue number4
Publication statusPublished - Jul 20 2012

Fingerprint

Alkaloids
Tumors
alkaloids
Cells
Type I DNA Topoisomerase
adenocarcinoma
Neoplasms
Adenocarcinoma
DNA topoisomerase
DNA topoisomerase (ATP-hydrolysing)
drugs
Type II DNA Topoisomerase
Amaryllidaceae
cervix
Cervix Uteri
Pharmaceutical Preparations
breasts
carcinoma
Squamous Cell Carcinoma
Assays

Keywords

  • Arolycoricidine
  • Cytostaticity
  • Dna topoisomerases
  • Galanthus rizehensis
  • Narciprimine

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology
  • Plant Science

Cite this

Sarikaya, B. B., Zencir, S., Somer, N. U., Kaya, G. I., Onur, M. A., Bastida, J., ... Topcu, Z. (2012). The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity. Records of Natural Products, 6(4), 381-385.

The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity. / Sarikaya, Buket Bozkurt; Zencir, Sevil; Somer, Nehir Unver; Kaya, Gulen Irem; Onur, Mustafa Ali; Bastida, Jaume; Berenyi, Agnes; Zupkó, I.; Topcu, Zeki.

In: Records of Natural Products, Vol. 6, No. 4, 20.07.2012, p. 381-385.

Research output: Contribution to journalArticle

Sarikaya, BB, Zencir, S, Somer, NU, Kaya, GI, Onur, MA, Bastida, J, Berenyi, A, Zupkó, I & Topcu, Z 2012, 'The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity', Records of Natural Products, vol. 6, no. 4, pp. 381-385.
Sarikaya BB, Zencir S, Somer NU, Kaya GI, Onur MA, Bastida J et al. The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity. Records of Natural Products. 2012 Jul 20;6(4):381-385.
Sarikaya, Buket Bozkurt ; Zencir, Sevil ; Somer, Nehir Unver ; Kaya, Gulen Irem ; Onur, Mustafa Ali ; Bastida, Jaume ; Berenyi, Agnes ; Zupkó, I. ; Topcu, Zeki. / The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity. In: Records of Natural Products. 2012 ; Vol. 6, No. 4. pp. 381-385.
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