Az angiotenzinreceptor-blokkolók idegrendszeri hatásai hypertoniában és dementiában

Translated title of the contribution: The effects of angiotensin receptor blockers on the nervous system in hypertension and dementia

Research output: Contribution to journalArticle

Abstract

The renin-angiotensin system (RAS) is one of the most important mechanisms regarding the pathomechanism and treatment of hyprtension. The most of the elements of the RAS are found in the nervous system too. The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers (ARBs) is based on the inhibition of the RAS. ARBs might have a special role in the central nervous system because they do not decrease the production of angiotensin but inhibit its harmful effects mediated through the AT1 receptor while allowing the stimulation of AT2 receptors with resulting pleiotrophic actions. Hypertension is the most important risk factor for stroke and has a negative effect on cognitive functions. Antihypertensive treatment has an effect on the nervous system; in addition to the consequences of the reduced blood pressure, ARBs might provide additional advantages in stroke and dementia prevention.

Translated title of the contributionThe effects of angiotensin receptor blockers on the nervous system in hypertension and dementia
Original languageHungarian
Pages (from-to)611-618
Number of pages8
JournalLege Artis Medicinae
Volume23
Issue number12
Publication statusPublished - Dec 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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