The effects of anandamide (endogen cannabinoid) on prostaglandin synthesis in pregnant rat

G. Fragkakis, K. Probonas, P. Giannikou, N. Yiannakakis, T. Wenger

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Abstract

Cannabinoids cause increase in the number of stillbirths and delay of delivery. The recent identification and purification of anandamide (ANA), the putative endogenous ligand for the cannabinoid receptor, provided us the opportunity to investigate its effects on prostaglandin secretion in pregnant rats. We compared the consequences of Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marihuana with ANA after i.p, injection with a daily dose of 0.02 mg/kg, b.w., respectively over the third week of gestation. Both drugs caused a delay of pregnancy and lowered serum prostaglandin (PG)F 1α and PGF 2α. There were increased number of stillbirths in drug treated dams. We postulate that the delay of pregnancy and the augmentation of stillbirth is due to the low PG level.

Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalNeuroendocrinology Letters
Volume17
Issue number4
Publication statusPublished - Dec 1 1995

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Fragkakis, G., Probonas, K., Giannikou, P., Yiannakakis, N., & Wenger, T. (1995). The effects of anandamide (endogen cannabinoid) on prostaglandin synthesis in pregnant rat. Neuroendocrinology Letters, 17(4), 271-279.