The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

Zoltan Bori, Z. Zhao, E. Koltai, Ioannis G. Fatouros, Athanasios Z. Jamurtas, Ioannis I. Douroudos, Gerasimos Terzis, Athanasios Chatzinikolaou, Apostolos Sovatzidis, Dimitrios Draganidis, Istvan Boldogh, Z. Radák

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Aging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression profile of mitochondrial biogenesis, and fusion and fission related genes in skeletal muscle of human subjects. Physical activity attenuated the aging-associated decline in VO2 max (p2max and increased significantly in the young physically active group. Mitochondrial fission representing FIS1 was induced by regular physical activity, while a bout of exercise decreased fusion-associated gene expression. The expression of polynucleotide phosphorylase (PNPase) changed inversely in young and old groups and decreased with aging. The A2 subunit of cyclic AMP-activated protein kinase (AMPK) was induced by a single bout of exercise in skeletal muscle samples of both young and old subjects (p

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalExperimental Gerontology
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Mitochondrial Dynamics
Mitochondrial Proteins
Muscle
Skeletal Muscle
Aging of materials
Polyribonucleotide Nucleotidyltransferase
AMP-Activated Protein Kinases
Organelle Biogenesis
Fusion reactions
varespladib methyl
Cyclic AMP
Gene Expression
Gene expression
Genes

Keywords

  • Aging
  • Exercise
  • Fusion and fission
  • Mitochondrial biogenesis
  • Skeletal muscle

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. / Bori, Zoltan; Zhao, Z.; Koltai, E.; Fatouros, Ioannis G.; Jamurtas, Athanasios Z.; Douroudos, Ioannis I.; Terzis, Gerasimos; Chatzinikolaou, Athanasios; Sovatzidis, Apostolos; Draganidis, Dimitrios; Boldogh, Istvan; Radák, Z.

In: Experimental Gerontology, Vol. 47, No. 6, 06.2012, p. 417-424.

Research output: Contribution to journalArticle

Bori, Z, Zhao, Z, Koltai, E, Fatouros, IG, Jamurtas, AZ, Douroudos, II, Terzis, G, Chatzinikolaou, A, Sovatzidis, A, Draganidis, D, Boldogh, I & Radák, Z 2012, 'The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle', Experimental Gerontology, vol. 47, no. 6, pp. 417-424. https://doi.org/10.1016/j.exger.2012.03.004
Bori, Zoltan ; Zhao, Z. ; Koltai, E. ; Fatouros, Ioannis G. ; Jamurtas, Athanasios Z. ; Douroudos, Ioannis I. ; Terzis, Gerasimos ; Chatzinikolaou, Athanasios ; Sovatzidis, Apostolos ; Draganidis, Dimitrios ; Boldogh, Istvan ; Radák, Z. / The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. In: Experimental Gerontology. 2012 ; Vol. 47, No. 6. pp. 417-424.
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