The effects of a deproteinized blood extract on the myocardial changes developing during experimentally induced intermittent hypoxia

E. Somogyi, P. Sotonyi, A. Nemes

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Myocardial hypoxia induced by intermittent cross-clamping of the aorto-coronary bypass during closed-heart surgery provokes progressive derangement of the myocardial metabolism. The principal changes observed after 18 min of hypoxia (without protection) were a marked swelling of mitochondria, distortion of cristae, reduction in glycogen content, interstitial oedema, focal destruction of I-band material and coagulation necrosis of myofilaments. Another characteristic change is the decoupling of oxidative phosphorylation. These morphological and biochemical changes were successfully prevented by the administration of Solcoseryl (Actihaemyl), a dialysis concentrate from deproteinised calf blood. The less pronounced structural and functional mitochondrial changes in protected hearts suggest that the myocardium is able to tolerate a more severe hypoxia under Solcoseryl protection.

Original languageEnglish
Pages (from-to)1376-1381
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Volume29
Issue number9
Publication statusPublished - Dec 1 1979

ASJC Scopus subject areas

  • Drug Discovery

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