The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

János F. László, Judit Solténszky, R. Pórszász, Attila Kónya

Research output: Contribution to journalArticle

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p <0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalJournal of Complementary and Integrative Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Autoimmune Experimental Encephalomyelitis
Magnetic Fields
Multiple Sclerosis
Emulsions
Rodentia
Spinal Cord
Outcome Assessment (Health Care)
Control Groups
Research

Keywords

  • Experimental autoimmune encephalomyelitis (EAE)
  • Freund's complete adjuvant (FCA)
  • Mouse spinal cord homogenate (MSCH)
  • Multiple sclerosis (MS)
  • Pertussis toxin (PTX)
  • Static magnetic field (SMF)

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice. / László, János F.; Solténszky, Judit; Pórszász, R.; Kónya, Attila.

In: Journal of Complementary and Integrative Medicine, Vol. 11, No. 1, 2014, p. 19-25.

Research output: Contribution to journalArticle

@article{dd0093764a21426a8cd6b1665d3c9f6c,
title = "The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice",
abstract = "Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82{\%} (p <0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.",
keywords = "Experimental autoimmune encephalomyelitis (EAE), Freund's complete adjuvant (FCA), Mouse spinal cord homogenate (MSCH), Multiple sclerosis (MS), Pertussis toxin (PTX), Static magnetic field (SMF)",
author = "L{\'a}szl{\'o}, {J{\'a}nos F.} and Judit Solt{\'e}nszky and R. P{\'o}rsz{\'a}sz and Attila K{\'o}nya",
year = "2014",
doi = "10.1515/jcim-2013-0055",
language = "English",
volume = "11",
pages = "19--25",
journal = "Journal of Complementary and Integrative Medicine",
issn = "1553-3840",
publisher = "Berkeley Electronic Press",
number = "1",

}

TY - JOUR

T1 - The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

AU - László, János F.

AU - Solténszky, Judit

AU - Pórszász, R.

AU - Kónya, Attila

PY - 2014

Y1 - 2014

N2 - Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p <0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.

AB - Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p <0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.

KW - Experimental autoimmune encephalomyelitis (EAE)

KW - Freund's complete adjuvant (FCA)

KW - Mouse spinal cord homogenate (MSCH)

KW - Multiple sclerosis (MS)

KW - Pertussis toxin (PTX)

KW - Static magnetic field (SMF)

UR - http://www.scopus.com/inward/record.url?scp=84898657116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898657116&partnerID=8YFLogxK

U2 - 10.1515/jcim-2013-0055

DO - 10.1515/jcim-2013-0055

M3 - Article

VL - 11

SP - 19

EP - 25

JO - Journal of Complementary and Integrative Medicine

JF - Journal of Complementary and Integrative Medicine

SN - 1553-3840

IS - 1

ER -