The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

János F. László, Judit Solténszky, Róbert Pórszász, Attila Kónya

Research output: Contribution to journalArticle

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p < 0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalJournal of Complementary and Integrative Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Experimental autoimmune encephalomyelitis (EAE)
  • Freund's complete adjuvant (FCA)
  • Mouse spinal cord homogenate (MSCH)
  • Multiple sclerosis (MS)
  • Pertussis toxin (PTX)
  • Static magnetic field (SMF)

ASJC Scopus subject areas

  • Complementary and alternative medicine

Fingerprint Dive into the research topics of 'The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice'. Together they form a unique fingerprint.

  • Cite this