The effect of weight change over a 2-year period on inflammatory status in postmenopausal women

Barbara E. Cronin, Philip J. Allsopp, Mary M. Slevin, Pamela J. Magee, Tracy A. McCaffrey, B. Livingstone, J. J. Strain, Emeir M. McSorley

Research output: Contribution to journalArticle

Abstract

Background/objectives: Body fat distribution has been shown to be a predictor of adhesion molecule and inflammatory marker expression albeit the effect of modest weight change on concentrations of adhesion molecules and inflammatory markers in postmenopausal women are not fully understood. The primary aim was to investigate the effects of weight change on adhesion molecules and inflammatory markers over 24 months in postmenopausal women. Subjects/methods: Body composition was assessed in 254 healthy postmenopausal women using dual-energy X-ray absorptiometry (DXA). Adhesion molecules and inflammatory markers were analysed by multiplex ELISA. Participants weight gain/loss at 24 months was defined as any value that was either above/below the weight value recorded at baseline. Results: Postmenopausal women with an average weight loss of 3% had significantly decreased leptin concentrations by 18% at 24 months (P < 0.01). A 4% increase in body weight or a 9% increase in FMI significantly increased intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-α (TNF-α) and leptin concentrations in postmenopausal women at 24 months (P < 0.01). Conclusions: Modest weight loss in postmenopausal women has a lowering effect on leptin concentrations over 24 months which may improve inflammatory status whilst modest weight gain increases ICAM-1, leptin and TNF-α, markers which are associated with a pro-inflammatory state and vascular complications.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEuropean Journal of Clinical Nutrition
DOIs
Publication statusAccepted/In press - Nov 23 2017

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Leptin
Weights and Measures
Weight Loss
Intercellular Adhesion Molecule-1
Weight Gain
Tumor Necrosis Factor-alpha
Body Fat Distribution
Photon Absorptiometry
Body Composition
Blood Vessels
Enzyme-Linked Immunosorbent Assay
Body Weight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cronin, B. E., Allsopp, P. J., Slevin, M. M., Magee, P. J., McCaffrey, T. A., Livingstone, B., ... McSorley, E. M. (Accepted/In press). The effect of weight change over a 2-year period on inflammatory status in postmenopausal women. European Journal of Clinical Nutrition, 1-6. https://doi.org/10.1038/s41430-017-0014-9

The effect of weight change over a 2-year period on inflammatory status in postmenopausal women. / Cronin, Barbara E.; Allsopp, Philip J.; Slevin, Mary M.; Magee, Pamela J.; McCaffrey, Tracy A.; Livingstone, B.; Strain, J. J.; McSorley, Emeir M.

In: European Journal of Clinical Nutrition, 23.11.2017, p. 1-6.

Research output: Contribution to journalArticle

Cronin, Barbara E. ; Allsopp, Philip J. ; Slevin, Mary M. ; Magee, Pamela J. ; McCaffrey, Tracy A. ; Livingstone, B. ; Strain, J. J. ; McSorley, Emeir M. / The effect of weight change over a 2-year period on inflammatory status in postmenopausal women. In: European Journal of Clinical Nutrition. 2017 ; pp. 1-6.
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