The effect of viscosity on the apparent decomposition rate on enzyme-ligand complexes

B. Somogyi, Frank E. Karasz, L. Trón, Peter R. Couchma

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A theoretical model is presented for describing a previously untreated effect of viscosity on the apparent decomposition rate of enzyme-ligand complexes. Since the translational diffusion is hindered by the viscosity, its increased value results in an enlarged portion of ligands which can be rebound by the enzyme immediately after the dissociation of the complex. The model accounts for the experimentally observed decrease in maximal velocity of enzymic reactions at high viscosity. At the same time, it serves as a tool to obtain new information about the energetic processes of enzyme action.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalJournal of Theoretical Biology
Volume74
Issue number2
DOIs
Publication statusPublished - Sep 21 1978

Fingerprint

Viscosity
viscosity
Enzymes
Ligands
Decomposition
Decompose
degradation
enzymes
Rebound
enzymatic reactions
Theoretical Model
Immediately
Theoretical Models
Decrease
ligands
Model

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

The effect of viscosity on the apparent decomposition rate on enzyme-ligand complexes. / Somogyi, B.; Karasz, Frank E.; Trón, L.; Couchma, Peter R.

In: Journal of Theoretical Biology, Vol. 74, No. 2, 21.09.1978, p. 209-216.

Research output: Contribution to journalArticle

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