The effect of viscosity on the apparent decomposition rate on enzyme-ligand complexes

Béla Somogyi, Frank E. Karasz, Lajos Trón, Peter R. Couchma

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13 Citations (Scopus)

Abstract

A theoretical model is presented for describing a previously untreated effect of viscosity on the apparent decomposition rate of enzyme-ligand complexes. Since the translational diffusion is hindered by the viscosity, its increased value results in an enlarged portion of ligands which can be rebound by the enzyme immediately after the dissociation of the complex. The model accounts for the experimentally observed decrease in maximal velocity of enzymic reactions at high viscosity. At the same time, it serves as a tool to obtain new information about the energetic processes of enzyme action.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalJournal of Theoretical Biology
Volume74
Issue number2
DOIs
Publication statusPublished - Sep 21 1978

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ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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