The effect of veratrine on the ion transport of frog skeletal muscle

E. Varga, T. Kovacs, B. Szabo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The changes in Na, Li and K transport caused by veratrine in the frog sartorius muscle have been studied. 0.1 mM of veratrine increases Na influx to nearly three times the initial value in 15 minutes and in the presence of veratrine this increased influx is maintained for several housr. hours. of the same concentration raises Li influx, too (in 7 experiments by a mean factor of 2.5). Veratrine causes a temporary increase in Na efflux. This effect can be observed in Li Ringer's solution too, but in choline Ringer's solution there is no change in the Na efflux of veratrine treated muscles. There is no change in [Na]i after 15 to 30 minutes of veratrine treatment, but after 30 to 60 minutes of treatment [Na]i is almost 50%, after 61 to 200 minutes 80 to 90% higher than in the untreated controls. After 180 minutes [Li]i rises to 130%. This increase indicates at the same time that Na and Li influxes are more marked than the increase in the water content of the muscles which also appears consistently as an effect of veratrine treatment. Though veratrine causes a temporary rise in the K loss from the muscle, it is the increase in water content which is primarily responsible for the decrease of [K]i. The Na influx of muscle pretreated with 0.01 mM of veratrine was increased by 12.5 mM of K, though 0.01 mM of veratrine alone does not affect the Na influx and 12.5 mM of K alone reduces the Na influx.

Original languageEnglish
Pages (from-to)265-277
Number of pages13
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume41
Issue number3-4
Publication statusPublished - 1972

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Veratrine
Ion Transport
Anura
Skeletal Muscle
Muscles
Water
Choline

ASJC Scopus subject areas

  • Physiology

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The effect of veratrine on the ion transport of frog skeletal muscle. / Varga, E.; Kovacs, T.; Szabo, B.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 41, No. 3-4, 1972, p. 265-277.

Research output: Contribution to journalArticle

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