The Effect of Two Different Routes of Administration of Oxytocin on Peripheral Plasma Prostaglandin F Metabolite Levels in Early Post-partum Dairy Cows

Á C S Bajcsy, H. Kindahl, O. Szenci, G. C. van der Weijden, J. Bartyik, M. A M Taverne

Research output: Contribution to journalArticle

Abstract

Contents: Various parenteral treatment forms of oxytocin, as often used under praxis circumstances, may act differently on contractility of the uterus during the first days of the puerperium. Various patterns of such induced uterotonic responses may lead to alterations in the emptying characteristics of the uterine lumen, thus influencing, as a late consequence, the process of involution. Therefore, this study was designed to test whether two different parenteral administration forms of oxytocin induce changes in peripheral plasma concentrations of 15-ketodihydro-prostaglandin F (PGF metabolite) in early post-partum cows. Between 13 and 15h after uncomplicated calving, healthy dairy cows without retained foetal membranes were treated with 50IU oxytocin, either intramuscularly (OT-IM group; n=15) or intravenously (OT-IV group; n=16). Saline solution was administered intramuscularly as controls (CON group; n=15). Jugular blood samples were taken at 10-min intervals from 1h before to 2h after treatment. Plasma PGF metabolite levels were measured by radioimmunoassay. No significant differences in peripheral plasma PGF metabolite concentrations occurred in the OT-IM and CON groups, but mean values significantly increased in the OT-IV group, peaking at 20min after treatment and reaching pre-treatment baseline values again at 120min. Although the source of prostaglandins was not investigated in this study, our results suggest that exogenous oxytocin may enhance secretion of prostaglandins by the uterus during the first day after normal calving. These prostaglandins might contribute, by an endocrine or paracrine route, to the stimulation of myometrial contractility when exogenous oxytocin is given during this early post-partum stage.

Original languageEnglish
Pages (from-to)208-212
Number of pages5
JournalReproduction in Domestic Animals
Volume47
Issue number2
DOIs
Publication statusPublished - Apr 2012

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Dinoprost
oxytocin
Oxytocin
prostaglandins
dairy cows
metabolites
Prostaglandins
uterus
Uterus
calving
Extraembryonic Membranes
retained placenta
postpartum period
radioimmunoassays
Sodium Chloride
sodium chloride
Postpartum Period
normal values
neck
Radioimmunoassay

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biotechnology
  • Endocrinology

Cite this

The Effect of Two Different Routes of Administration of Oxytocin on Peripheral Plasma Prostaglandin F Metabolite Levels in Early Post-partum Dairy Cows. / Bajcsy, Á C S; Kindahl, H.; Szenci, O.; van der Weijden, G. C.; Bartyik, J.; Taverne, M. A M.

In: Reproduction in Domestic Animals, Vol. 47, No. 2, 04.2012, p. 208-212.

Research output: Contribution to journalArticle

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