The effect of tp-3 (arg-lys-asp), tp-4 (arg-lys-asp-val), and tp-5 on the metastatic capacity of intravenously injected lewis lung tumor cells

B. Szende, K. Lapis, K. Pal, L. Sipos, L. Denes, L. Kisfaludy

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The oligopeptides Arg-Lys-Asp (TP-3), Arg-Lys-Asp-Val (TP-4), and Arg-Lys-Asp-Val-Tyr (TP-5) considered as the active short fragments of thymopoietin were administered (lo mg/kg) to C57BI mice 24 hours before the intravenous inoculation of Lewis lung tumor (LLT) cells. A substantial decrease in lung metastasis number was observed as a result of treatment with all of the three oligopeptides. TP-3, TP-4, and TP-5 treatment decreased the immunosuppressive activity of Cyclophosphamid (240 mg/kg) given 96 hours before the inoculation of LLT cells. After thymectomy, performed eight days before the LLT inoculation, only TP-3 treatment resulted in the decrease of Cyclophosphamid immunotoxicity. A stimulating effect of TP-3 on T helper cell activity is assumed. The oligopeptides TP-3, TP-4, and TP-5 are recommended for clinical trial in case of malignant tumors and immunodeficiency.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalImmunopharmacology and Immunotoxicology
Issue number1
Publication statusPublished - Jan 1 1987


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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