The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in Guinea pigs

L. Dénes, Gy Hajós, L. Szporny, B. Szende, K. Lapis, S. Sipka, Gy Szegedi

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3 Citations (Scopus)

Abstract

Suramin administration inhibits virus replication and produces impaired immuno-regulation. Delayed type hypersensitivity (DTH)-reaction was inhibited by Suramin (200 mg/kg, i.p.) injection in guinea-pigs immunized with BCG vaccine. Suramin-inhibited DTH-reaction was restored to normal level after 4 days of treatment with thymopoietin 32-34 (TP 3) and TP5 (1 mg/kg, i.p.), TP3 > TP5. TP3 produced the strongest restoration when applied together with Suramin, but a single treatment with TP3 or TP5 oligopeptide inhibited the development of DTH-reaction. TP3 with Suramin treatment might be advantageous to eliminate defective side effects of Suramin on immune system and TP3 with indirect inducing action on IL-2, IFN-gamma production may be useful in therapy of AIDS patients.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalImmunological Investigations
Volume16
Issue number4
DOIs
Publication statusPublished - Jan 1 1987

ASJC Scopus subject areas

  • Immunology

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