The effect of the ring size of fused chelates on the thermodynamic and spectroscopic properties of peptide complexes of copper(II)

Daniele Sanna, Csaba Gábor Ágoston, Giovanni Micera, I. Sóvágó

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Copper(II) complexes of the tripeptides GlyGly-β-Ala, Gly-β-AlaGly, β-AlaGlyGly, Gly-β-Ala-β-Ala, β-AlaGly-β-Ala, β-Ala-β-Ala-β-Ala and the tetrapeptides GlyGlyGly-β-Ala, GlyGly-β-AlaGly, Gly-β-AlaGlyGly and β-AlaGlyGlyGly were studied by potentiometric, EPR and UV-Vis spectroscopic methods. The stoichiometry of the complexes of peptides containing β-alanine residues are very similar to those of oligoglycines; [CuL]+, [CuL2], [CuH-1L], [CuH-2L]-, [CuH-1L2]- and [CuH-3L]2- were detected as the major species in all cases. The presence of β-alanine residues, however, influenced both thermodynamic stability and coordination geometry of various complexes. In most cases the formation of six-membered chelate rings resulted in a decrease of thermodynamic stability and distortion of coordination geometry of peptide complexes, especially if β-alanine residues were present in N-terminal or adjacent positions. On the contrary, the formation of the mixed (5,6,5) and (5,5,6) linked chelate systems of tripeptides is favoured over the pure five-membered rings.

Original languageEnglish
Pages (from-to)3079-3090
Number of pages12
JournalPolyhedron
Volume20
Issue number26-27
DOIs
Publication statusPublished - Dec 1 2001

Fingerprint

alanine
Thermodynamics
chelates
Alanine
Peptides
peptides
Copper
Thermodynamic stability
thermodynamic properties
copper
Geometry
rings
Stoichiometry
Paramagnetic resonance
thermodynamics
geometry
stoichiometry

Keywords

  • β-alanine
  • Chelate ring size
  • Copper(II) complexes
  • EPR
  • Peptides
  • Potentiometry

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

The effect of the ring size of fused chelates on the thermodynamic and spectroscopic properties of peptide complexes of copper(II). / Sanna, Daniele; Ágoston, Csaba Gábor; Micera, Giovanni; Sóvágó, I.

In: Polyhedron, Vol. 20, No. 26-27, 01.12.2001, p. 3079-3090.

Research output: Contribution to journalArticle

Sanna, Daniele ; Ágoston, Csaba Gábor ; Micera, Giovanni ; Sóvágó, I. / The effect of the ring size of fused chelates on the thermodynamic and spectroscopic properties of peptide complexes of copper(II). In: Polyhedron. 2001 ; Vol. 20, No. 26-27. pp. 3079-3090.
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