The data presented here show that the gonads, gonadotrophic hormones, large doses of sexual steroids or androgen sterilization have no effect on the acquisition of the conditioned avoidance behaviour. Removal of the gonads before puberty will delay extinction, however, after puberty the intervention is ineffective. Large doses of HCG will facilitate extinction, decrease intertrial and open field activity. This action is not mediated by the adrenals. Sexual steroids in general have the opposite effect on extinction and intertrial activity but have no effect on exploratory activity. The effect of androgen sterilization on extinction is also a facilitatory one. Whether the action of sexual steroids is primary or secondary remains to be established. It seems that large doses of gonadotrophic hormone and sexual steroids have an opposite effect on the extinction of conditioned avoidance behaviour. It is generally accepted that the extinction of conditioned avoidance response is due to the action of internal inhibitory processes. Facilitation of extinction can be regarded as an enhanced internal inhibition. In support of this hypothesis a number of evidences have been presented in connection with the action of corticosteroids (Endroczi and Lissak 1962, Lissak and Endoczi 1964, Bohus and Endroczi 1965). On the basis of the present postulation human chorionic gonadotrophin which facilitates the extinction in large doses enhances internal inhibitory processes. Sexual steroids by decreasing the internal inhibition delay the extinction of the conditioned avoidance response.
|Number of pages||19|
|Publication status||Published - Jan 1 1976|
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