The effect of the eutectic composition on the outcome of kinetically and thermodynamically controlled resolutions that are based on the formation of diastereomers

Zsolt Szeleczky, Péter Bagi, Emese Pálovics, Elemér Fogassy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The resolution of mandelic acid and its derivatives with free amino acids has been investigated. It was observed that the corresponding diastereomers were formed under either kinetic or thermodynamic control, which considerably influenced the purity of the enantiomeric mixtures obtained. It was found that in these particular resolutions, the eutectic composition of either the racemic compound or the resolving agent influenced the purity of the enantiomeric mixtures of the mandelic acid derivatives obtained after resolution.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalTetrahedron Asymmetry
Volume26
Issue number7
DOIs
Publication statusPublished - Apr 15 2015

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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