The effect of systemically and locally administered steroids on VIP-like immunoreactive cells in the paraventricular nucleus of adrenalectomized rats

L. Bartha, D. T. Kiem, G. B. Makara

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Abstract

Seven days after adrenalectomy (ADX) the number of vasoactive intestinal peptide (VIP)- and corticotropin-releasing factor (CRF)-immunoreactive cells in the parvocellular part of the rat paraventricular nucleus (PVN) increased markedly. Dexamethasone in the drinking water (started immediately after ADX) or its local implantation around the hypothalamic PVN reduced the ADX-induced increase in the number of VIP- and CRF-like immunoreactive neurons. The present results suggest that PVN might be the site at which glucocorticoids inhibit the increase in VIP-positive cells after ADX.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalBrain research
Volume506
Issue number2
DOIs
Publication statusPublished - Jan 8 1990

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Keywords

  • Dexamethasone
  • Immunocytochemistry
  • Sex steroid
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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